This brief provides a comprehensive overview of the role and challenges of commercial, professional, and domestic refrigeration within the global cold chain. These systems are essential for preserving food, medicines, and vaccines, yet they face persistent issues related to temperature control, energy consumption, and refrigerant emissions. The cold chain remains vulnerable to inefficiencies, especially in its final stages, where inconsistent temperatures and poor maintenance practices can compromise product safety and increase environmental impact. Despite technological progress, a significant share of products still exceeds recommended temperature thresholds, and energy use remains high across all sectors.




